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Advances in the Application of Pd-Mediated Transformations in Nucleotides and Oligonucleotides

Show simple item record WALUNJ, MANISHA B. en_US Sabale, Pramod M. en_US SRIVATSAN, SEERGAZHI G. en_US 2018-06-28T04:17:39Z 2018-06-28T04:17:39Z 2018-01 en_US
dc.identifier.citation Palladium-Catalyzed Modification of Nucleosides, Nucleotides and Oligonucleotides en_US
dc.description.abstract Developments in aqueous-phase Pd-catalyzed cross-coupling reactions have provided new opportunities to directly functionalize nucleotides and oligonucleotides (ONs) for a variety of applications, which range from diagnosis to biophysical analysis of nucleic acids to therapeutics. In this review, we first provide a detailed discussion on how chemists have developed and judiciously applied Pd-mediated reactions like Suzuki–Miyaura, Sonogashira, Stille and Heck to synthesize modified nucleotide analogs suitable for enzymatic labeling of nucleic acids. Particular emphasis is given to the applications of labeled ONs derived from incorporation of such modified nucleotides. Following this, new applications of Pd-mediated cross-coupling reactions to postsynthetically functionalize ONs with various biophysical reporters are presented. en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.subject Cross-coupling en_US
dc.subject Functionalized nucleotides en_US
dc.subject Nucleotides en_US
dc.subject Oligonucleotides en_US
dc.subject Oligonucleotide labeling en_US
dc.subject Palladium en_US
dc.subject TOC-JUNE-2018 en_US
dc.subject 2018 en_US
dc.title Advances in the Application of Pd-Mediated Transformations in Nucleotides and Oligonucleotides en_US
dc.type Book chapter en_US
dc.contributor.department Dept. of Biology en_US
dc.identifier.doi en_US
dc.publication.originofpublisher Foreign en_US

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