scalable synthesis of sodium oligomannate for alzheimer's and neurodegenerative diseases

Abstract

Alzheimer's is a devastating neurodegenerative disorder with limited effective treatment options. Sodium oligomannates are emerging as promising agents for targeting amyloid-beta and tau interactions in Alzheimer’s therapy. As part of our continued interest in the synthesis of oligosaccharides of therapeutic significance, we chose to develop a streamlined, scalable synthesis of oliomannuronates by employing the Crich method for the β-mannosylation and, subsequently, in situ-generated RuO4-mediated reductive opening of the benzylidenes, and apart from this route, we have also tried different routes to reach the oligosaccharide We believe that the strategy will accelerate the development of next-generation therapeutics by making structurally defined oligomannuronates, including full-length and truncated forms, widely accessible. The results of this Project shown in this thesis