Digital Repository

A role of neuropeptide CART in hyperphagia and weight gain induced by olanzapine treatment in rats

Show simple item record

dc.contributor.author Nakhate, Kartik T. en_US
dc.contributor.author SUBHEDAR, NISHIKANT K. en_US
dc.contributor.author Kokare, Dadasaheb M. en_US
dc.date.accessioned 2018-08-16T04:56:13Z
dc.date.available 2018-08-16T04:56:13Z
dc.date.issued 2018-09 en_US
dc.identifier.citation Brain Research, 1695. en_US
dc.identifier.issn 1872-6240 en_US
dc.identifier.uri http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1136
dc.identifier.uri https://doi.org/10.1016/j.brainres.2018.05.014 en_US
dc.description.abstract Although olanzapine is highly efficacious and most widely used second generation antipsychotic drug, the success of treatment has been hampered by its propensity to induce weight gain. While the underlying neuronal mechanisms are unclear, their elucidation may help to target alternative pathways regulating energy balance. The present study was undertaken to define the role of cocaine- and amphetamine regulated transcript (CART), a well-known anorexic peptide, in olanzapine-induced hyperphagia and body weight gain in female rats. Olanzapine was administered daily by intraperitoneal route, alone or in combination with CART (intracerebroventricular) for a period of two weeks. Immediately after drug administrations, preweighed food was offered to the animals at the commencement of the dark phase. The food intake and body weight were measured daily just prior to next injection. Furthermore, the brains of olanzapine-treated rats were processed for the immunohistochemical analysis of CART containing elements in the hypothalamus. Treatment with olanzapine (0.5 mg/kg) for the duration of 14 days produced a significant increase in food intake and body weight as compared to control. However, concomitant administration of CART (0.5 mu g) attenuated the olanzapine-induced hyperphagia and weight gain. Olanzapine administration resulted in a significant reduction in CART immunoreactivity in the hypothalamic arcuate, paraventricular, dorsomedial and ventromedial nuclei. We suggest that decreased CART contents in the hypothalamus may be causally linked with the hyperphagia and weight gain induced by olanzapine. en_US
dc.language.iso en en_US
dc.publisher Elsevier B.V. en_US
dc.subject 2018 en_US
dc.subject CART en_US
dc.subject Food intake en_US
dc.subject Body weight en_US
dc.subject lmmunohistochemistry en_US
dc.subject TOC-AUG-2018 en_US
dc.title A role of neuropeptide CART in hyperphagia and weight gain induced by olanzapine treatment in rats en_US
dc.type Article en_US
dc.contributor.department Dept. of Biology en_US
dc.identifier.sourcetitle Brain Research en_US
dc.publication.originofpublisher Foreign en_US


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search Repository


Advanced Search

Browse

My Account