Glycosylated PROLI/NO Derivatives as Nitric Oxide Prodrugs

dc.contributor.author	Nandurdikar, Rahul S.	en_US
dc.contributor.author	Maciag, Anna E.	en_US
dc.contributor.author	Hong, Sam Y.	en_US
dc.contributor.author	CHAKRAPANI, HARINATH	en_US
dc.contributor.author	Citro, Michael L.	en_US
dc.contributor.author	Keefer, Larry K.	en_US
dc.contributor.author	Saavedra, Joseph E.	en_US
dc.date.accessioned	2019-01-21T10:29:25Z
dc.date.available	2019-01-21T10:29:25Z
dc.date.issued	2009-12	en_US
dc.identifier.citation	Organic Letters, 12(1), 56-59.	en_US
dc.identifier.issn	1523-7060	en_US
dc.identifier.issn	1523-7052	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1485
dc.identifier.uri	https://doi.org/10.1021/ol902481s	en_US
dc.description.abstract	GlcNAc-PROLI/NO prodrugs that are activated by N-acetylglucosaminidase to release nitric oxide (NO) are described. A classical acid-amine coupling is used to bifunctionalize these PROLI/NO prodrugs, which on activation generate up to 4 mol of NO, a peptide residue, and an N-acetylglucosamine residue. Many of the prodrugs synthesized are efficient sources of intracellular NO.	en_US
dc.language.iso	en	en_US
dc.publisher	American Chemical Society	en_US
dc.subject	PROLI/NO	en_US
dc.subject	lysine methyl	en_US
dc.subject	Glycosidase	en_US
dc.subject	Peptide residue	en_US
dc.subject	2010	en_US
dc.title	Glycosylated PROLI/NO Derivatives as Nitric Oxide Prodrugs	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Chemistry	en_US
dc.identifier.sourcetitle	Organic Letters	en_US
dc.publication.originofpublisher	Foreign	en_US