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Enhanced stability of G-quadruplexes from conformationally constrained aep-PNA backbone

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dc.contributor.author GANESH, KRISHNA N. en_US
dc.contributor.author Sharma, Nagendra K. en_US
dc.date.accessioned 2019-01-21T10:29:25Z
dc.date.available 2019-01-21T10:29:25Z
dc.date.issued 2011-02 en_US
dc.identifier.citation Organic and Biomolecular Chemistry, (9). en_US
dc.identifier.issn 1477-0520 en_US
dc.identifier.issn 1477-0539 en_US
dc.identifier.uri http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1488
dc.identifier.uri https://doi.org/10.1039/C0OB00528B en_US
dc.description.abstract Nucleic (DNA) acids having contiguous stretch of G sequence form quadruplex structure, which is very critical to control cell division. Recently the existence of G-quadruplex in RNA is also reported in presence of monovalent metal ion. PNA is a promising DNA analogue which binds strongly to DNA to form PNA-:-DNA duplex or PNA2-:-DNA triplex. PNA also forms quadruplexes such G-quadruplex and i-motif in G and C-rich sequences respectively. aep-PNA containing a prolyl ring is one of several PNA analogues that provide rigidity and chirality in backbone and has binding affinity to natural DNA which is higher than that of PNA. Here we examine the ability of aep-PNA-G to form a quadruplex by UV, CD and mass spectroscopic techniques. en_US
dc.language.iso en en_US
dc.publisher Royal Society of Chemistry en_US
dc.subject Nucleic (DNA) en_US
dc.subject PNA analogues en_US
dc.subject G-quadruplex en_US
dc.subject Monovalent metal en_US
dc.subject 2011 en_US
dc.title Enhanced stability of G-quadruplexes from conformationally constrained aep-PNA backbone en_US
dc.type Article en_US
dc.contributor.department Dept. of Chemistry en_US
dc.identifier.sourcetitle Organic and Biomolecular Chemistry en_US
dc.publication.originofpublisher Foreign en_US


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