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In situ, on-resin synthesis of 8-Br/NH2 adeninyl peptide nucleic acid (PNA) oligomers and complementation studies with DNA

In situ, on-resin synthesis of 8-Br/NH2 adeninyl peptide nucleic acid (PNA) oligomers and complementation studies with DNA

Vysabhattar, Raman; GANESH, KRISHNA N.
URI: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1489
https://doi.org/10.1016/j.tetlet.2010.10.040
Date: 2010-12


Abstract:

A new, novel and efficient in situ synthesis of 8-aminoadeninyl PNA oligomers from corresponding 8-bromoadeninyl PNA oligomers is reported. The study of hybridisation properties of (8-Br/8-NH2) PNA oligomers with cDNA reveals substitution-site dependent stabilization of derived triplexes and duplexes.

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