Novel self-assembled lithocholic acid nanoparticles for drug delivery in cancer

Shende, Shrikant; Jadhav, Shraddha; BASU, SUDIPTA; Gawali, Suhas; PATIL, SOHAN; Patil, Sumersing

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dc.contributor.author	Patil, Sumersing	en_US
dc.contributor.author	PATIL, SOHAN	en_US
dc.contributor.author	Gawali, Suhas	en_US
dc.contributor.author	Shende, Shrikant	en_US
dc.contributor.author	Jadhav, Shraddha	en_US
dc.contributor.author	BASU, SUDIPTA	en_US
dc.date.accessioned	2019-02-14T05:00:08Z
dc.date.available	2019-02-14T05:00:08Z
dc.date.issued	2013-08	en_US
dc.identifier.citation	RSC Advances, 3(43), 19760-19764.	en_US
dc.identifier.issn	2046-2069	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1581
dc.identifier.uri	https://doi.org/10.1039/C3RA42994F	en_US
dc.description.abstract	Novel versatile self-assembled nanoparticles were developed from biocompatible, biodegradable lithocholic acid derivatives. These nanoparticles can incorporate different cytotoxic drugs (paclitaxel and doxorubicin) and PI3K signalling inhibitor (PI103). Drugs were released from the nanoparticles in a slow, sustained manner at acidic pH. The drug loaded nanoparticles were internalized through lysosomal compartments and induced cell death in HeLa cervical cancer cells.	en_US
dc.language.iso	en	en_US
dc.publisher	Royal Society of Chemistry	en_US
dc.subject	Lithocholic acid	en_US
dc.subject	Nanoparticles for drug	en_US
dc.subject	Cancer cells	en_US
dc.subject	Cytotoxic drugs	en_US
dc.subject	Acidic pH	en_US
dc.subject	2013	en_US
dc.title	Novel self-assembled lithocholic acid nanoparticles for drug delivery in cancer	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Chemistry	en_US
dc.identifier.sourcetitle	RSC Advances	en_US
dc.publication.originofpublisher	Foreign	en_US