INDQ/NO, a Bioreductively Activated Nitric Oxide Prodrug

dc.contributor.author	Sharma, Kavita	en_US
dc.contributor.author	Iyer, Aishwarya	en_US
dc.contributor.author	SENGUPTA, KUNDAN	en_US
dc.contributor.author	CHAKRAPANI, HARINATH	en_US
dc.date.accessioned	2019-02-14T05:00:09Z
dc.date.available	2019-02-14T05:00:09Z
dc.date.issued	2013-06	en_US
dc.identifier.citation	Organic Letters, 15(11), 2636-2639.	en_US
dc.identifier.issn	1523-7060	en_US
dc.identifier.issn	1523-7052	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1587
dc.identifier.uri	https://doi.org/10.1021/ol400884v	en_US
dc.description.abstract	The design, synthesis, and development of INDQ/NO, a novel nitric oxide (NO) prodrug targeted by a bioreductive trigger, are described. INDQ/NO, an indolequinone-diazeniumdiolate is found to be metabolized to produce NO by DT-diaphorase, a bioreductive enzyme that is overexpressed in certain cancers and hypoxic tumors. Cell-based assays revealed that INDQ/NO induces DNA damage and is a potent inhibitor of cancer cell proliferation.	en_US
dc.language.iso	en	en_US
dc.publisher	American Chemical Society	en_US
dc.subject	INDQ/NO	en_US
dc.subject	Bioreductively	en_US
dc.subject	Nitric Oxide Prodrug	en_US
dc.subject	Tumoristatic agent	en_US
dc.subject	Two-electron reductase	en_US
dc.subject	Reactive nitrogen	en_US
dc.subject	2013	en_US
dc.title	INDQ/NO, a Bioreductively Activated Nitric Oxide Prodrug	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Chemistry	en_US
dc.identifier.sourcetitle	Organic Letters	en_US
dc.publication.originofpublisher	Foreign	en_US