A highly selective sulfinate ester probe for thiol bioimaging

MALWAL, SATISH R.; CHAKRAPANI, HARINATH; Labade, Ajay; SENGUPTA, KUNDAN; Andhalkar, Abhijeet S.

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A highly selective sulfinate ester probe for thiol bioimaging

MALWAL, SATISH R.; Labade, Ajay; Andhalkar, Abhijeet S.; SENGUPTA, KUNDAN; CHAKRAPANI, HARINATH

URI: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1925 https://doi.org/10.1039/C4CC05462H Date: 2014-08

Abstract:

We describe here hitherto unexplored chemistry of the sulfinate ester functional group as being highly selective towards nucleophilic substitution by thiols at physiological pH. Using this cleavable trigger, an optical thiol probe that is suitable for thiol bioimaging has been developed.

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