A Small Molecule for Controlled Generation of Reactive Oxygen Species (ROS)

dc.contributor.author	DHARMARAJA, ALLIMUTHU T.	en_US
dc.contributor.author	CHAKRAPANI, HARINATH	en_US
dc.date.accessioned	2019-02-25T09:00:43Z
dc.date.available	2019-02-25T09:00:43Z
dc.date.issued	2014-01	en_US
dc.identifier.citation	Organic Letters, 16(2), 398-401.	en_US
dc.identifier.issn	1523-7060	en_US
dc.identifier.issn	1523-7052	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1928
dc.identifier.uri	https://doi.org/10.1021/ol403300a	en_US
dc.description.abstract	Due to the short half-life of reactive oxygen species (ROS) such as a superoxide radical, controlled and localized generation of ROS is challenging. Here, we report a rationally designed small-molecule 1c that generates ROS only when triggered by a bacterial enzyme. We provide evidence for 1c predictably enhancing the intracellular superoxide radical in a model bacterium. Spatiotemporal control over ROS generation offered by 1c should help better understand stress responses in bacteria to increased ROS.	en_US
dc.language.iso	en	en_US
dc.publisher	American Chemical Society	en_US
dc.subject	Small Molecule	en_US
dc.subject	Controlled Generation	en_US
dc.subject	Oxygen Species	en_US
dc.subject	Bacteria to increased ROS	en_US
dc.subject	2014	en_US
dc.title	A Small Molecule for Controlled Generation of Reactive Oxygen Species (ROS)	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Chemistry	en_US
dc.identifier.sourcetitle	Organic Letters	en_US
dc.publication.originofpublisher	Foreign	en_US