Clickable Cγ-Azido(methylene/butylene) Peptide Nucleic Acids and Their Clicked Fluorescent Derivatives: Synthesis, DNA Hybridization Properties, and Cell Penetration Studies

GANESH, KRISHNA N.; Jain, Deepak R.

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dc.contributor.author	Jain, Deepak R.	en_US
dc.contributor.author	GANESH, KRISHNA N.	en_US
dc.date.accessioned	2019-02-25T09:00:43Z
dc.date.available	2019-02-25T09:00:43Z
dc.date.issued	2014-07	en_US
dc.identifier.citation	Journal of Organic Chemistry, 79(14), 6708-6714.	en_US
dc.identifier.issn	0022-3263	en_US
dc.identifier.issn	1520-6904	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/1930
dc.identifier.uri	https://doi.org/10.1021/jo500834u	en_US
dc.description.abstract	Synthesis, characterization, and DNA complementation studies of clickable Cγ-substituted methylene (azm)/butylene (azb) azido PNAs show that these analogues enhance the stability of the derived PNA:DNA duplexes. The fluorescent PNA oligomers synthesized by their click reaction with propyne carboxyfluorescein are seen to accumulate around the nuclear membrane in 3T3 cells.	en_US
dc.language.iso	en	en_US
dc.publisher	American Chemical Society	en_US
dc.subject	Fluorescent Derivatives	en_US
dc.subject	Peptide Nucleic Acid	en_US
dc.subject	DNA Hybridization	en_US
dc.subject	Cell Penetration Studies	en_US
dc.subject	Carboxyfluorescein	en_US
dc.subject	Nuclear membrane	en_US
dc.subject	2014	en_US
dc.title	Clickable Cγ-Azido(methylene/butylene) Peptide Nucleic Acids and Their Clicked Fluorescent Derivatives: Synthesis, DNA Hybridization Properties, and Cell Penetration Studies	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Chemistry	en_US
dc.identifier.sourcetitle	Journal of Organic Chemistry	en_US
dc.publication.originofpublisher	Foreign	en_US