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Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients.

Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients.

Ujjwal Neogi; Shwetha Rao; Irene Bontell; Jens Verheyen; Vasudev Rao; Sagar Gore; Neelesh Soni; Anita Shet; Eugen Schlter; Maria Ekstrand; Amogne Wondwossen; Rolf Kaiser; MADHUSUDHAN, M. S.; Vinayaka Prasad; Anders Sonnerborg
URI: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2065
https://doi.org/10.1097/QAD.0000000000000419
Date: 2014-09


Abstract:

A novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region, which appeared in protease inhibitor failure Indian HIV-1C sequences (odds ratio=17.1, P < 0.001) but was naturally present in half of untreated Ethiopian HIV-1C sequences. The insertion is predicted to restore ALIX-mediated virus release pathway, which is lacking in HIV-1C. The clinical importance of the insertion needs to be evaluated in HIV-1C dominating regions wherein the use of protease inhibitor drugs are being scaled up.

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