Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients.

Ujjwal Neogi; Rolf Kaiser; Vasudev Rao; Eugen Schlter; Neelesh Soni; MADHUSUDHAN, M. S.; Anders Sonnerborg; Shwetha Rao; Amogne Wondwossen; Jens Verheyen; Anita Shet; Maria Ekstrand; Sagar Gore; Vinayaka Prasad; Irene Bontell

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dc.contributor.author	Ujjwal Neogi	en_US
dc.contributor.author	Shwetha Rao	en_US
dc.contributor.author	Irene Bontell	en_US
dc.contributor.author	Jens Verheyen	en_US
dc.contributor.author	Vasudev Rao	en_US
dc.contributor.author	Sagar Gore	en_US
dc.contributor.author	Neelesh Soni	en_US
dc.contributor.author	Anita Shet	en_US
dc.contributor.author	Eugen Schlter	en_US
dc.contributor.author	Maria Ekstrand	en_US
dc.contributor.author	Amogne Wondwossen	en_US
dc.contributor.author	Rolf Kaiser	en_US
dc.contributor.author	MADHUSUDHAN, M. S.	en_US
dc.contributor.author	Vinayaka Prasad	en_US
dc.contributor.author	Anders Sonnerborg	en_US
dc.date.accessioned	2019-02-25T09:04:43Z
dc.date.available	2019-02-25T09:04:43Z
dc.date.issued	2014-09	en_US
dc.identifier.citation	AIDS, 28(15),2319 2322.	en_US
dc.identifier.issn	2319 2322	en_US
dc.identifier.issn	1473-5571	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2065
dc.identifier.uri	https://doi.org/10.1097/QAD.0000000000000419	en_US
dc.description.abstract	A novel tetra-peptide insertion was identified in Gag-p6 ALIX-binding region, which appeared in protease inhibitor failure Indian HIV-1C sequences (odds ratio=17.1, P < 0.001) but was naturally present in half of untreated Ethiopian HIV-1C sequences. The insertion is predicted to restore ALIX-mediated virus release pathway, which is lacking in HIV-1C. The clinical importance of the insertion needs to be evaluated in HIV-1C dominating regions wherein the use of protease inhibitor drugs are being scaled up.	en_US
dc.language.iso	en	en_US
dc.publisher	Lippincott, Williams & Wilkins	en_US
dc.subject	Novel tetra-peptide	en_US
dc.subject	HIV-1 subtype	en_US
dc.subject	Indian patients	en_US
dc.subject	Protease inhibitor drugs	en_US
dc.subject	2014	en_US
dc.title	Novel tetra-peptide insertion in Gag-p6 ALIX-binding motif in HIV-1 subtype C associated with protease inhibitor failure in Indian patients.	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Biology	en_US
dc.identifier.sourcetitle	AIDS	en_US
dc.publication.originofpublisher	Foreign	en_US