Synthesis and Characterization of Hybrid peptides Containing Gamma- and Vinylogous amino acids

Abstract

In contrast to the beta- and alpha/beta-peptides, the progress in the gamma, alpha/gamma and beta/gamma-hybrid peptides is lagging behind. This is probably due to the difficulty in obtaining stereochemically pure double homologated gamma4-amino acids. In this project, we are describing the synthesis of stereochemically pure gamma4-amino acids and their utilization in the solid phase synthesis of hybrid octapeptides. The gamma4-amino acids were synthesized starting from the protected alpha-amino acids through Wittig reaction. The structural analysis of the peptides is under progress.