A 1,3-amino group migration route to form acrylamidines

Chauhan, Dinesh Pratapsinh; Varma, Sreejith Jayasree; BANERJEE, PALLAVI; TALUKDAR, PINAKI; Vijeta, Arjun

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A 1,3-amino group migration route to form acrylamidines

Chauhan, Dinesh Pratapsinh; Varma, Sreejith Jayasree; Vijeta, Arjun; BANERJEE, PALLAVI; TALUKDAR, PINAKI

URI: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2103 https://doi.org/10.1039/C3CC47182A Date: 2013-10

Abstract:

A novel 1,3-amino group migration strategy for the synthesis of acrylamidines is presented. Cu(I) catalyzed reaction of N,N-disubstituted propargylamine with tosylazide generates a highly reactive ketenimine intermediate which is trapped by a tethered amino group leading to the rearrangement reaction.

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