Design of Stable β-Hairpin Mimetics through Backbone Disulfide Bonds

GOPI, HOSAHUDYA N.; MALI, SACHITANAND M.; Kumar, Mothukuri Ganesh; Raja, K. Muruga Poopathi

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dc.contributor.author	Kumar, Mothukuri Ganesh	en_US
dc.contributor.author	MALI, SACHITANAND M.	en_US
dc.contributor.author	Raja, K. Muruga Poopathi	en_US
dc.contributor.author	GOPI, HOSAHUDYA N.	en_US
dc.date.accessioned	2019-03-15T11:22:37Z
dc.date.available	2019-03-15T11:22:37Z
dc.date.issued	2015-01	en_US
dc.identifier.citation	Organic Letters, 17 (2), 230-233.	en_US
dc.identifier.issn	1523-7060	en_US
dc.identifier.issn	1523-7052	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2145
dc.identifier.uri	https://doi.org/10.1021/ol503310r	en_US
dc.description.abstract	The synthesis and utilization of novel thiostatines (β-SH-substituted γ-amino acids) in the design of backbone-disulfide-stabilized β-hairpin mimetics, solution conformations of hybrid β-hairpins and Cys-disulfide-stabilized α-peptide analogue, their thiol exchange, and proteolytic stability are investigated. The results suggest that thiostatines can be used to design proteolytically stable water-soluble β-hairpin mimetics without deviating from overall β-hairpin conformation.	en_US
dc.language.iso	en	en_US
dc.publisher	American Chemical Society	en_US
dc.subject	Design of Stable β-Hairpin	en_US
dc.subject	Disulfide Bonds	en_US
dc.subject	Stable protein secondary structure	en_US
dc.subject	Antimicrobial peptides	en_US
dc.subject	2015	en_US
dc.title	Design of Stable β-Hairpin Mimetics through Backbone Disulfide Bonds	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Chemistry	en_US
dc.identifier.sourcetitle	Organic Letters	en_US
dc.publication.originofpublisher	Foreign	en_US