Sialic Acid Hydroxamate: A Potential Antioxidant and Inhibitor of Metal‐Induced β‐Amyloid Aggregates

Murthy, Raghavendra Vasudeva; KIKKERI, RAGHAVENDRA; Yadav, Rohan

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dc.contributor.author	Yadav, Rohan	en_US
dc.contributor.author	Murthy, Raghavendra Vasudeva	en_US
dc.contributor.author	KIKKERI, RAGHAVENDRA	en_US
dc.date.accessioned	2019-03-15T11:23:08Z
dc.date.available	2019-03-15T11:23:08Z
dc.date.issued	2015-07	en_US
dc.identifier.citation	ChemBioChem, 16(10), 1448-1453.	en_US
dc.identifier.issn	1439-4227	en_US
dc.identifier.issn	1439-7633	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2162
dc.identifier.uri	https://doi.org/10.1002/cbic.201500162	en_US
dc.description.abstract	Current methods for Alzheimer's treatment require a three‐component system: metal chelators, antioxidants, and amyloid β (Aβ)‐peptide‐binding scaffolds. We report sialic acid (Sia) hydroxamate as a potential radical scavenger and metal chelator to inhibit Aβ aggregation. A cell viability assay revealed that Sia hydroxamate can protect HeLa and glioblastoma (LN229) cells from oxidative damage induced by the Fenton reaction. Sedimentation and turbidity assays showed profound protection of neuroblastoma SH‐SY5Y cells from metal‐induced Aβ aggregation and neural toxicity.	en_US
dc.language.iso	en	en_US
dc.publisher	Wiley	en_US
dc.subject	Sialic Acid Hydroxamate	en_US
dc.subject	Potential Antioxidant	en_US
dc.subject	??Amyloid Aggregates	en_US
dc.subject	Alzheimer's treatment	en_US
dc.subject	2015	en_US
dc.title	Sialic Acid Hydroxamate: A Potential Antioxidant and Inhibitor of Metal‐Induced β‐Amyloid Aggregates	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Chemistry	en_US
dc.identifier.sourcetitle	ChemBioChem	en_US
dc.publication.originofpublisher	Foreign	en_US