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A conformation-specific IR spectroscopic signature for weak C O⋯C O n→π* interaction in capped 4R-hydroxyproline

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dc.contributor.author SINGH, SANTOSH K. en_US
dc.contributor.author More, Shahaji en_US
dc.contributor.author KUMAR, SATISH en_US
dc.contributor.author MISHRA, KAMAL K. en_US
dc.contributor.author Ganesh, Krishna N. en_US
dc.contributor.author DAS, ALOKE en_US
dc.date.accessioned 2019-03-26T10:01:03Z
dc.date.available 2019-03-26T10:01:03Z
dc.date.issued 2019-02 en_US
dc.identifier.citation Physical Chemistry Chemical Physics, 21(9), 4755-4762. en_US
dc.identifier.issn 1463-9076 en_US
dc.identifier.issn 1463-9084 en_US
dc.identifier.uri http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2375
dc.identifier.uri https://doi.org/10.1039/C8CP07660J en_US
dc.description.abstract Collagen, the most abundant protein in animals, has a unique triple helical structure comprising three parallel left-handed polyproline II (PPII) strands while each of the strands consists of a repeating sequence of X–Y–Gly, where X = proline (Pro) and Y = 4-hydroxyproline (Hyp). Collagen forms a stable triple helix of very long polypeptide strands despite the absence of intra-strand hydrogen bonding in the individual polypeptide chains. It has been reported that non-covalent n→π* interaction plays a significant role in stabilizing the individual polypeptide strands in collagen. However, there is no direct spectroscopic evidence for the presence of this interaction in collagen or its building block. Herein, we have observed for the first time a conformation-specific IR spectroscopic signature for C[double bond, length as m-dash]O⋯C[double bond, length as m-dash]O n→π*-amide interaction in a capped Hyp residue, the most important monomer building block of collagen, using isolated gas phase IR spectroscopy and quantum chemistry calculations. The proof of the existence of this interaction in a model monomer has implications for better understanding of its role not only in structures of collagen but also most of the other proteins and larger peptides. en_US
dc.language.iso en en_US
dc.publisher Royal Society of Chemistry en_US
dc.subject Chemistry en_US
dc.subject TOC-MAR-2019 en_US
dc.subject 2019 en_US
dc.title A conformation-specific IR spectroscopic signature for weak C O⋯C O n→π* interaction in capped 4R-hydroxyproline en_US
dc.type Article en_US
dc.contributor.department Dept. of Chemistry en_US
dc.identifier.sourcetitle Physical Chemistry Chemical Physics en_US
dc.publication.originofpublisher Foreign en_US


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