Perfluoroalkylchain conjugation as a new tactic for enhancing cell permeability of peptide nucleic acids (PNAs) via reducing the nanoparticle size

Murthy, Raghavendra Vasudeva; GANESH, KRISHNA N.; Ellipilli, Satheesh

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dc.contributor.author	Ellipilli, Satheesh	en_US
dc.contributor.author	Murthy, Raghavendra Vasudeva	en_US
dc.contributor.author	GANESH, KRISHNA N.	en_US
dc.date.accessioned	2019-04-26T09:12:30Z
dc.date.available	2019-04-26T09:12:30Z
dc.date.issued	2015-10	en_US
dc.identifier.citation	Chemical Communications, 52(3), 521-524 .	en_US
dc.identifier.issn	1359-7345	en_US
dc.identifier.issn	1364-548X	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2494
dc.identifier.uri	https://doi.org/10.1039/C5CC05342K	en_US
dc.description.abstract	Perfluoro undecanoyl chain conjugated peptide nucleic acids (PNAs) show 2.5 to 3 fold higher cellular uptake efficiency in NIH 3T3 and HeLa cells compared to simple undecanoyl PNAs. Fluorination of PNAs leads to the formation of lower size (∼100–250 nm) nanoparticles compared to larger size (∼500 nm) nanoparticles from non-fluorinated PNAs, thereby improving the efficiency of cell penetration.	en_US
dc.language.iso	en	en_US
dc.publisher	Royal Society of Chemistry	en_US
dc.subject	New tactic	en_US
dc.subject	Cell permeability	en_US
dc.subject	Peptide nucleic acids	en_US
dc.subject	Reducing the nanoparticle size	en_US
dc.subject	Lipids to promote	en_US
dc.subject	2016	en_US
dc.title	Perfluoroalkylchain conjugation as a new tactic for enhancing cell permeability of peptide nucleic acids (PNAs) via reducing the nanoparticle size	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Chemistry	en_US
dc.identifier.sourcetitle	Chemical Communications	en_US
dc.publication.originofpublisher	Foreign	en_US