Isolation and Characterization of Bioactive Benzofuran Sesquiterpene from Marine Sponge Ircinia Fusca (Carter, 1880)

Mokashe, Satish S.; WATVE, MILIND; Lakwal, Vijay R.; Kharate, Dinesh S.; Meesala, Srinu

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dc.contributor.author	Meesala, Srinu	en_US
dc.contributor.author	Lakwal, Vijay R.	en_US
dc.contributor.author	Kharate, Dinesh S.	en_US
dc.contributor.author	Mokashe, Satish S.	en_US
dc.contributor.author	WATVE, MILIND	en_US
dc.date.accessioned	2019-04-29T09:21:00Z
dc.date.available	2019-04-29T09:21:00Z
dc.date.issued	2016-08	en_US
dc.identifier.citation	Journal of Chemical, Biological and Physical Sciences, 6(4), 1400-1418.	en_US
dc.identifier.issn	2249 -1929	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2622
dc.identifier.uri	-	en_US
dc.description.abstract	A novel benzofuran sesquiterpene derivative:7-methyl-7-((E)-4-methylpenta1,3-dien-1-yl)-5,6,7,7a-tetrahydrobenzofuran-3a(4H)-ol(Iricinol A), was isolated from a marine sponge Ircinia fusca (Carter, 1880). The structure of the compound was elucidated by using 1D, 2DNMR, and ESI-MS-TOF. The compound showed broad-spectrum activity against bacteria and fungi at 2 µg/µL. Also, it exhibited in vitro cytotoxic activity against RAW264.7 cells (mouse monotype macrophage leukemia) and N2A cells (neuroblastoma) with IC50 values 55 ± 4.21 µg/mL.	en_US
dc.language.iso	en	en_US
dc.publisher	JCBPSC	en_US
dc.subject	Sponge	en_US
dc.subject	Sesquiterpenes	en_US
dc.subject	NMR & Mass spectrometry	en_US
dc.subject	Natural Products	en_US
dc.subject	Antimicrobial anticancer activity	en_US
dc.subject	Marine organisms	en_US
dc.subject	2016	en_US
dc.title	Isolation and Characterization of Bioactive Benzofuran Sesquiterpene from Marine Sponge Ircinia Fusca (Carter, 1880)	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Biology	en_US
dc.identifier.sourcetitle	Journal of Chemical	en_US
dc.publication.originofpublisher	Indian	en_US