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Extratropical anticyclonic Rossby wave breaking and Indian summer monsoon failure

Show simple item record Samanta, Dhrubajyoti en_US Dash, M. K. en_US GOSWAMI, B. N. en_US Pandey, P. C. en_US 2019-04-29T09:25:02Z 2019-04-29T09:25:02Z 2016-03 en_US
dc.identifier.citation Climate Dynamics, 46(5-6), 1547-1562. en_US
dc.identifier.issn 1007-1027 en_US
dc.identifier.issn 1432-0894 en_US
dc.identifier.uri en_US
dc.description.abstract The global incidence of tuberculosis is increasing at an alarming rate, and Mycobacterium tuberculosis (Mtb) is the causative agent for tuberculosis, a disease with high mortality. Lipoarabinomannan (LAM) is one of the major components of the Mtb cellular envelope and is an attractive scaffold for developing anti-tubercular drugs, vaccines and diagnostics. Herein, a highly convergent strategy is developed to synthesize heneicosasaccharyl arabinomannan for the first time. The arabinomannan synthesized in this endeavour has several 1,2-trans or α-Araf linkages and three 1,2-cis or β-Araf linkages end capped with 1,2-trans or α-Manp linkages. All the key glycosidations were performed with alkynyl carbonate glycosyl donors under [Au]/[Ag] catalysis conditions, which gave excellent yields and stereoselectivity even for the reactions between complex and branched oligosaccharides. The resultant allyl oligosaccharide was globally deprotected to obtain the heneicosasaccharyl arabinomannan as a propyl glycoside. In summary, heneicosasaccharyl mannose capped arabinomannan synthesis was achieved in 56 steps with 0.016% overall yield. en_US
dc.language.iso en en_US
dc.publisher Springer Nature en_US
dc.subject Extratropical anticyclonic en_US
dc.subject Rossby wave en_US
dc.subject Indian summer monsoon failure en_US
dc.subject Mdratitude disturbances en_US
dc.subject Rossby wave breaking en_US
dc.subject Indian summer monsoon en_US
dc.subject Blocking Monsoonal convection en_US
dc.subject 2016 en_US
dc.title Extratropical anticyclonic Rossby wave breaking and Indian summer monsoon failure en_US
dc.type Article en_US
dc.contributor.department Dept. of Earth and Climate Science en_US
dc.identifier.sourcetitle Climate Dynamics en_US
dc.publication.originofpublisher Foreign en_US

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