A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines

Parsons, William H.; KAMAT, SIDDHESH S.; Ogura, Yuji; Cravatt, Benjamin F

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dc.contributor.author	Ogura, Yuji	en_US
dc.contributor.author	Parsons, William H.	en_US
dc.contributor.author	KAMAT, SIDDHESH S.	en_US
dc.contributor.author	Cravatt, Benjamin F	en_US
dc.date.accessioned	2019-04-29T09:25:03Z
dc.date.available	2019-04-29T09:25:03Z
dc.date.issued	2016-07	en_US
dc.identifier.citation	Nature Chemical Biology, 12(9), 669-671.	en_US
dc.identifier.issn	1552-4450	en_US
dc.identifier.issn	1552-4469	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2646
dc.identifier.uri	https://doi.org/10.1038/nchembio.2127	en_US
dc.description.abstract	More than 30 years ago, a calcium-dependent enzyme activity was described that generates N-acyl phosphatidylethanolamines (NAPEs), which are precursors for N-acyl ethanolamine (NAE) lipid transmitters, including the endocannabinoid anandamide. The identity of this calcium-dependent N-acyltransferase (Ca-NAT) has remained mysterious. Here, we use activity-based protein profiling to identify the poorly characterized serine hydrolase PLA2G4E as a mouse brain Ca-NAT and show that this enzyme generates NAPEs and NAEs in mammalian cells.	en_US
dc.language.iso	en	en_US
dc.publisher	Nature Publishing Group	en_US
dc.subject	Calcium-dependent enzyme	en_US
dc.subject	N-acyltransferase	en_US
dc.subject	NAEs are a class of bioactive lipids	en_US
dc.subject	Brain Ca-NAT	en_US
dc.subject	PLA2G4E	en_US
dc.subject	2016	en_US
dc.title	A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Biology	en_US
dc.identifier.sourcetitle	Nature Chemical Biology	en_US
dc.publication.originofpublisher	Foreign	en_US