Screening of Neu5Acα(2–6)gal isomer preferences of siglecs with a sialic acid microarray

Ben Arye, Shani Leviatan; Yadav, Rohan; SUBRAMANI, BALAMURUGAN; KIKKERI, RAGHAVENDRA; Padler-Karavani, Vered

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dc.contributor.author	Yadav, Rohan	en_US
dc.contributor.author	Ben Arye, Shani Leviatan	en_US
dc.contributor.author	SUBRAMANI, BALAMURUGAN	en_US
dc.contributor.author	Padler-Karavani, Vered	en_US
dc.contributor.author	KIKKERI, RAGHAVENDRA	en_US
dc.date.accessioned	2019-04-29T10:14:35Z
dc.date.available	2019-04-29T10:14:35Z
dc.date.issued	2016-09	en_US
dc.identifier.citation	Organic and Biomolecular Chemistry, 14(46), 10812-10815.	en_US
dc.identifier.issn	1477-0520	en_US
dc.identifier.issn	1477-0539	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2662
dc.identifier.uri	https://doi.org/10.1039/C6OB01688J	en_US
dc.description.abstract	Sialic acids (Sias) are important terminal sugars on cell surfaces involved in a wide range of protein–carbohydrate interactions. Hence, agents modulating sias-mediated protein interactions are promising inhibitors or vaccine candidates. Here, we report the synthesis of Neu5Acα(2–6)Gal structural analogs and their binding to a series of siglecs. The results showed distinct binding patterns with conserved siglecs (hCD22 and mCD22) compared to rapid evolving siglecs (Siglecs -3 & -10).	en_US
dc.language.iso	en	en_US
dc.publisher	Royal Society of Chemistry	en_US
dc.subject	Screening of Neu5Ac?	en_US
dc.subject	Sialic acid microarray	en_US
dc.subject	Glycoproteins	en_US
dc.subject	Immune responses	en_US
dc.subject	Tumorigenesis	en_US
dc.subject	2016	en_US
dc.title	Screening of Neu5Acα(2–6)gal isomer preferences of siglecs with a sialic acid microarray	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Chemistry	en_US
dc.identifier.sourcetitle	Organic and Biomolecular Chemistry	en_US
dc.publication.originofpublisher	Foreign	en_US