A Small Molecule for Controlled Generation of Peroxynitrite

CHAKRAPANI, HARINATH; Kulkarni, Apoorva; KHODADE, VINAYAK S.; Sen Gupta, Ayantika; SENGUPTA, KUNDAN

DR Home
→
PUBLICATIONS & PATENTS
→
JOURNAL ARTICLES
→
View Item

dc.contributor.author	KHODADE, VINAYAK S.	en_US
dc.contributor.author	Kulkarni, Apoorva	en_US
dc.contributor.author	Sen Gupta, Ayantika	en_US
dc.contributor.author	SENGUPTA, KUNDAN	en_US
dc.contributor.author	CHAKRAPANI, HARINATH	en_US
dc.date.accessioned	2019-04-29T10:14:35Z
dc.date.available	2019-04-29T10:14:35Z
dc.date.issued	2016-03	en_US
dc.identifier.citation	Organic Letters,18 (6), 1274-1277.	en_US
dc.identifier.issn	1523-7060	en_US
dc.identifier.issn	1523-7052	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/2670
dc.identifier.uri	https://doi.org/10.1021/acs.orglett.6b00186	en_US
dc.description.abstract	2-Methyl-3-[1-(N,N-dimethylamino)diazen-1-ium-1,2-diol-2-ato-methyl]-naphthalene-1,4-dione 1 (HyPR-1), a small molecule containing a superoxide generator strategically linked to a diazeniumdiolate-based nitric oxide donor, is reported. Evidence for HyPR-1’s ability to generate peroxynitrite in the presence of an enzyme as well as enhance peroxynitrite within cells is provided. The utility of this tool in generating peroxynitrite for cellular studies is demonstrated.	en_US
dc.language.iso	en	en_US
dc.publisher	American Chemical Society	en_US
dc.subject	Controlled Generation of Peroxynitrite	en_US
dc.subject	Peroxynitrite	en_US
dc.subject	Small molecule containing a superoxide	en_US
dc.subject	Nitric oxide	en_US
dc.subject	2016	en_US
dc.title	A Small Molecule for Controlled Generation of Peroxynitrite	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Biology	en_US
dc.identifier.sourcetitle	Organic Letters	en_US
dc.publication.originofpublisher	Foreign	en_US