Abstract:
In past two decades, there has been a global surge in the number of drug resistant
pathogens. This can be accounted to the indiscriminate use of antibiotics. The
increased global drug resistant bacterias pose a serious health hazard in upcoming
decades while global pharmaceutical companies just try to maximise their profits. In
this context, Diphenyleneiodonium chloride (DPIC) a known inhibitor of
NADH/NADPH has been reported as a potent antibacterial molecule against M. Tb
and S.aureus. Based on this fact a series of pyridine derivatives of DPI (PPI)
compounds were synthesised and were evaluated against gram-negative and
gram-positive bacteria. All the compounds exhibit strong antimicrobial activity against
gram-negative, gram-positive bacteria. Diphenyl iodonium (DPI) has considerably
less antibacterial activity against gram-negative bacteria compared to phenylpyridine
iodonium (PPI) which showed very good antibacterial activity against gram-positive
as well as gram-negative bacteria. PPI shows very promising antibacterial activity it
has the potential of being an antibacterial agent.
