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Dmrt5, a Novel Neurogenic Factor, Reciprocally Regulates Lhx2 to Control the Neuron-Glia Cell-Fate Switch in the Developing Hippocampus

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dc.contributor.author Muralidharan, Bhavana en_US
dc.contributor.author Keruzore, Marc en_US
dc.contributor.author Pradhan, Saurabh J. en_US
dc.contributor.author Roy, Basabdatta en_US
dc.contributor.author Shetty, Ashwin S. en_US
dc.contributor.author Kinare, Veena en_US
dc.contributor.author D'Souza, Leora en_US
dc.contributor.author Maheshwari, Upasana en_US
dc.contributor.author KARMODIYA, KRISHANPAL en_US
dc.contributor.author Suresh, Agasthya en_US
dc.contributor.author GALANDE, SANJEEV en_US
dc.contributor.author Bellefroid,Eric J. en_US
dc.contributor.author Tole, Shubha en_US
dc.date.accessioned 2019-07-01T05:31:29Z
dc.date.available 2019-07-01T05:31:29Z
dc.date.issued 2017-11 en_US
dc.identifier.citation Journal of Neuroscience, 37(46), 11245-11254 en_US
dc.identifier.issn 0270-6474 en_US
dc.identifier.issn 0270-6474 en_US
dc.identifier.uri http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3171
dc.identifier.uri https://doi.org/10.1523/JNEUROSCI.1535-17.2017 en_US
dc.description.abstract Regulation of the neuron–glia cell-fate switch is a critical step in the development of the CNS. Previously, we demonstrated that Lhx2 is a necessary and sufficient regulator of this process in the mouse hippocampal primordium, such that Lhx2 overexpression promotes neurogenesis and suppresses gliogenesis, whereas loss of Lhx2 has the opposite effect. We tested a series of transcription factors for their ability to mimic Lhx2 overexpression and suppress baseline gliogenesis, and also to compensate for loss of Lhx2 and suppress the resulting enhanced level of gliogenesis in the hippocampus. Here, we demonstrate a novel function of Dmrt5/Dmrta2 as a neurogenic factor in the developing hippocampus. We show that Dmrt5, as well as known neurogenic factors Neurog2 and Pax6, can each not only mimic Lhx2 overexpression, but also can compensate for loss of Lhx2 to different extents. We further uncover a reciprocal regulatory relationship between Dmrt5 and Lhx2, such that each can compensate for loss of the other. Dmrt5 and Lhx2 also have opposing regulatory control on Pax6 and Neurog2, indicating a complex bidirectionally regulated network that controls the neuron–glia cell-fate switch. en_US
dc.language.iso en en_US
dc.publisher Society for Neuroscience en_US
dc.subject Cell fate en_US
dc.subject Glia en_US
dc.subject Hippocampus en_US
dc.subject Neuron en_US
dc.subject 2017 en_US
dc.title Dmrt5, a Novel Neurogenic Factor, Reciprocally Regulates Lhx2 to Control the Neuron-Glia Cell-Fate Switch in the Developing Hippocampus en_US
dc.type Article en_US
dc.contributor.department Dept. of Biology en_US
dc.identifier.sourcetitle Journal of Neuroscience en_US
dc.publication.originofpublisher Foreign en_US


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