FeCl3·6H2O catalyzed diastereoselective synthesis of (L)-menthyl 4-oxo-2-arylpiperidine-3-carboxylates

Abstract

An efficient diastereoselective synthesis of substituted piperidines is accomplished by using catalytic amount of FeCl3·6H2O via intramolecular aza-Michael addition of carbamate on alkylidene β-keto (L)-menthyl esters in a very short time.