Esterase Activated Carbonyl Sulfide/Hydrogen Sulfide (H2S) Donors

CHAKRAPANI, HARINATH; RAVIKUMAR, GOVINDAN; Jos, Swetha; BORA, PRERONA; Chauhan, Preeti

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Esterase Activated Carbonyl Sulfide/Hydrogen Sulfide (H2S) Donors

Chauhan, Preeti; BORA, PRERONA; RAVIKUMAR, GOVINDAN; Jos, Swetha; CHAKRAPANI, HARINATH

URI: http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3209 https://doi.org/10.1021/acs.orglett.6b03336 Date: 2017-01

Abstract:

Hydrogen sulfide (H2S) is a mediator of a number of cellular processes, and modulating cellular levels of this gas has emerged as an important therapeutic area. Localized generation of H2S is thus very useful but highly challenging. Here, we report pivaloyloxymethyl-based carbonothioates and carbamothioates that are activated by the enzyme, esterase, to generate carbonyl sulfide (COS), which is hydrolyzed to H2S.

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