Esterase Activated Carbonyl Sulfide/Hydrogen Sulfide (H2S) Donors

dc.contributor.author	Chauhan, Preeti	en_US
dc.contributor.author	BORA, PRERONA	en_US
dc.contributor.author	RAVIKUMAR, GOVINDAN	en_US
dc.contributor.author	Jos, Swetha	en_US
dc.contributor.author	CHAKRAPANI, HARINATH	en_US
dc.date.accessioned	2019-07-01T05:33:18Z
dc.date.available	2019-07-01T05:33:18Z
dc.date.issued	2017-01	en_US
dc.identifier.citation	Organic Letters, 19 (1), 62-65.	en_US
dc.identifier.issn	1523-7060	en_US
dc.identifier.issn	1523-7052	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3209
dc.identifier.uri	https://doi.org/10.1021/acs.orglett.6b03336	en_US
dc.description.abstract	Hydrogen sulfide (H2S) is a mediator of a number of cellular processes, and modulating cellular levels of this gas has emerged as an important therapeutic area. Localized generation of H2S is thus very useful but highly challenging. Here, we report pivaloyloxymethyl-based carbonothioates and carbamothioates that are activated by the enzyme, esterase, to generate carbonyl sulfide (COS), which is hydrolyzed to H2S.	en_US
dc.language.iso	en	en_US
dc.publisher	American Chemical Society	en_US
dc.subject	Esterase Activated Carbonyl	en_US
dc.subject	Sulfide (H2S) Donors	en_US
dc.subject	Carbonyl sulfide (COS)	en_US
dc.subject	H2S donors	en_US
dc.subject	COS/H2S	en_US
dc.subject	2017	en_US
dc.title	Esterase Activated Carbonyl Sulfide/Hydrogen Sulfide (H2S) Donors	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Chemistry	en_US
dc.identifier.sourcetitle	Organic Letters	en_US
dc.publication.originofpublisher	Foreign	en_US