A small molecule for theraNOstic targeting of cancer cells

CHAKRAPANI, HARINATH; RAVIKUMAR, GOVINDAN; Bagheri, Meisam; Saini, Deepak Kumar

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dc.contributor.author	RAVIKUMAR, GOVINDAN	en_US
dc.contributor.author	Bagheri, Meisam	en_US
dc.contributor.author	Saini, Deepak Kumar	en_US
dc.contributor.author	CHAKRAPANI, HARINATH	en_US
dc.date.accessioned	2019-07-01T05:33:18Z
dc.date.available	2019-07-01T05:33:18Z
dc.date.issued	2017-11	en_US
dc.identifier.citation	Chemical Communications, 53(61), 8592-8595.	en_US
dc.identifier.issn	1359-7345	en_US
dc.identifier.issn	1364-548X	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3210
dc.identifier.uri	https://doi.org/10.1039/C7CC08526E	en_US
dc.description.abstract	Thera/NO – a small molecule that is activated by hydrogen peroxide to generate nitric oxide (NO) and a fluorescence signal is reported. Using cancer and primary cells, we show that Thera/NO preferentially releases NO in cancer cells, which can trigger DNA damage and cell death in them. The coupled fluorescence signal facilitated tracking the NO release in living cells without collateral consumption of NO.	en_US
dc.language.iso	en	en_US
dc.publisher	Royal Society of Chemistry	en_US
dc.subject	Small molecule	en_US
dc.subject	theraNOstic targeting	en_US
dc.subject	Cancer cells	en_US
dc.subject	Cytotoxic effect of compound	en_US
dc.subject	Fluorophore	en_US
dc.subject	Fluorescence corresponding	en_US
dc.subject	2017	en_US
dc.title	A small molecule for theraNOstic targeting of cancer cells	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Chemistry	en_US
dc.identifier.sourcetitle	Chemical Communications	en_US
dc.publication.originofpublisher	Foreign	en_US