dc.contributor.author |
Reja, Rahi M. |
en_US |
dc.contributor.author |
Sunny, Sereena |
en_US |
dc.contributor.author |
GOPI, HOSAHUDYA N. |
en_US |
dc.date.accessioned |
2019-07-01T05:33:51Z |
|
dc.date.available |
2019-07-01T05:33:51Z |
|
dc.date.issued |
2017-07 |
en_US |
dc.identifier.citation |
Organic Letters, 19 (13), 3572-3575. |
en_US |
dc.identifier.issn |
1523-7060 |
en_US |
dc.identifier.issn |
1523-7052 |
en_US |
dc.identifier.uri |
http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3238 |
|
dc.identifier.uri |
https://doi.org/10.1021/acs.orglett.7b01498 |
en_US |
dc.description.abstract |
Synthesis and incorporation of a new amino acid with a nitroalkane side chain into peptides, in situ transformation of a nitroalkane side chain into nitrile oxide, and chemoselective 1,3-dipolar cycloaddition reactions between in situ generated nitrile oxide and different alkynes are reported. The nitroalkane-mediated nitrile oxide–alkyne cycloaddition was found to be orthogonal to the copper(I)-catalyzed azide–alkyne cycloaddition reaction. The combination of orthogonal nitrile oxide–alkyne and azide–alkyne cycloaddition reactions can be explored to tailor different 1,2,3-triazole and 3,5-isoxazoles, respectively, on the peptide backbone. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
American Chemical Society |
en_US |
dc.subject |
Chemoselective Nitrile Oxide-Alkyne |
en_US |
dc.subject |
Cycloaddition Reactions |
en_US |
dc.subject |
Nitroalkane-Tethered Peptides |
en_US |
dc.subject |
Cycloaddition reactions |
en_US |
dc.subject |
2017 |
en_US |
dc.title |
Chemoselective Nitrile Oxide–Alkyne 1,3-Dipolar Cycloaddition Reactions from Nitroalkane-Tethered Peptides |
en_US |
dc.type |
Article |
en_US |
dc.contributor.department |
Dept. of Chemistry |
en_US |
dc.identifier.sourcetitle |
Organic Letters |
en_US |
dc.publication.originofpublisher |
Foreign |
en_US |