Transition-Metal-Free CH Hydroxylation of Carbonyl Compounds

Sutar, Yogesh; MALPATHAK, SHREYAS; GNANAPRAKASAM, BOOPATHY; HAZRA, ANIRBAN; CHAUDHARI, MORESHWAR B.

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dc.contributor.author	CHAUDHARI, MORESHWAR B.	en_US
dc.contributor.author	Sutar, Yogesh	en_US
dc.contributor.author	MALPATHAK, SHREYAS	en_US
dc.contributor.author	HAZRA, ANIRBAN	en_US
dc.contributor.author	GNANAPRAKASAM, BOOPATHY	en_US
dc.date.accessioned	2019-07-01T05:34:34Z
dc.date.available	2019-07-01T05:34:34Z
dc.date.issued	2017-07	en_US
dc.identifier.citation	Organic Letters, 19 (13), 3628-3631.	en_US
dc.identifier.issn	1523-7060	en_US
dc.identifier.issn	1523-7052	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3242
dc.identifier.uri	https://doi.org/10.1021/acs.orglett.7b01616	en_US
dc.description.abstract	Transition metal and reductant free ?-C(sp3)-H hydroxylation of carbonyl compounds are reported. This method is promoted by commercially available inexpensive KO-t-Bu and atmospheric air as an oxidant at room temperature. This unified strategy is also very facile for hydroxylation of various carbonyl compound derivatives to obtain quaternary hydroxyl compounds in excellent yield. A preliminary mechanistic investigation, supported by isotope labeling and computational studies, suggests the formation of a peroxide bond and its cleavage by in situ generated enolate.	en_US
dc.language.iso	en	en_US
dc.publisher	American Chemical Society	en_US
dc.subject	Transition-Metal-Free	en_US
dc.subject	C-H Hydroxylation	en_US
dc.subject	Carbonyl Compounds	en_US
dc.subject	Hydrocarbons	en_US
dc.subject	Organic synthesis	en_US
dc.subject	2017	en_US
dc.title	Transition-Metal-Free CH Hydroxylation of Carbonyl Compounds	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Chemistry	en_US
dc.identifier.sourcetitle	Organic Letters	en_US
dc.publication.originofpublisher	Foreign	en_US