Design, Synthesis, and Evaluation of Thiol-Activated Sources of Sulfur Dioxide (SO2) as Antimycobacterial Agents

dc.contributor.author	Malwal, Satish	en_US
dc.contributor.author	Sriram, Dharmarajan	en_US
dc.contributor.author	Yogeeswari, Perumal	en_US
dc.contributor.author	Konkimalla, V. Badireenath	en_US
dc.contributor.author	CHAKRAPANI, HARINATH	en_US
dc.date.accessioned	2019-07-23T11:08:15Z
dc.date.available	2019-07-23T11:08:15Z
dc.date.issued	2011-11	en_US
dc.identifier.citation	The Journal of Medicinal Chemistry, 55(1), 553-557.	en_US
dc.identifier.issn	0022-2623	en_US
dc.identifier.issn	1520-4804	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3602
dc.identifier.uri	https://doi.org/10.1021/jm201023g	en_US
dc.description.abstract	Here, 2,4-dinitrophenylsulfonamides with tunable cysteine-activated SO2 release profiles with half-lives of SO2 release varying from 2 to 63 min are reported. N-Benzyl-2,4-dinitrobenzenesulfonamide (6), which is prepared in one step from commercial sources, had a potency (MIC = 0.15 μM) of inhibiting Mycobacterium tuberculosis (Mtb) higher than the clinical agent isoniazid (MIC = 0.37 μM).	en_US
dc.language.iso	en	en_US
dc.publisher	American Chemical Society	en_US
dc.subject	Chemistry	en_US
dc.subject	2011	en_US
dc.title	Design, Synthesis, and Evaluation of Thiol-Activated Sources of Sulfur Dioxide (SO2) as Antimycobacterial Agents	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Chemistry	en_US
dc.identifier.sourcetitle	The Journal of Medicinal Chemistry	en_US
dc.publication.originofpublisher	Foreign	en_US