Synthesis, thiol-mediated reactive oxygen species generation profiles and anti-proliferative activities of 2,3-epoxy-1,4-naphthoquinones

dc.contributor.author	DHARMARAJA, ALLIMUTHU T.	en_US
dc.contributor.author	Dash, Tapan K.	en_US
dc.contributor.author	Konkimalla, V. Badireenath	en_US
dc.contributor.author	CHAKRAPANI, HARINATH	en_US
dc.date.accessioned	2019-07-23T11:08:16Z
dc.date.available	2019-07-23T11:08:16Z
dc.date.issued	2012-01	en_US
dc.identifier.citation	MedChemCommun, 3(2), 219-224.	en_US
dc.identifier.issn	2040-2503	en_US
dc.identifier.issn	2040-2511	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3604
dc.identifier.uri	https://doi.org/10.1039/C1MD00234A	en_US
dc.description.abstract	Here, we report that thiol-mediated decomposition of 2,3-epoxy-1,4-naphthoquinones to generate peroxide, a reactive oxygen species (ROS), could be modulated by changing the substitution pattern on the aryl ring and the epoxide. Epoxides which generated higher amounts of peroxide upon reaction with thiols were better inhibitors of human leukaemia (THP1) cell proliferation.	en_US
dc.language.iso	en	en_US
dc.publisher	Royal Society of Chemistry	en_US
dc.subject	Chemistry	en_US
dc.subject	2012	en_US
dc.title	Synthesis, thiol-mediated reactive oxygen species generation profiles and anti-proliferative activities of 2,3-epoxy-1,4-naphthoquinones	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Chemistry	en_US
dc.identifier.sourcetitle	MedChemCommun	en_US
dc.publication.originofpublisher	Foreign	en_US