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Nucleophilic Addition Reactions on Glycosyl 1,2-Orthoesters

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dc.contributor.advisor HOTHA, SRINIVAS en_US
dc.contributor.author A. P, RAVI RAJA en_US
dc.date.accessioned 2014-05-06T11:14:08Z
dc.date.available 2014-05-06T11:14:08Z
dc.date.issued 2014-05 en_US
dc.identifier.uri http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/362
dc.description.abstract 1,2-trans glycosides can be synthesized in a stereoselective manner through glycosyl 1,2-orthoesters. The utility of the protocol was demonstrated by the stereoselective synthesis of various carbohydrate epitopes present in infectious bacteria exploiting salient features of gold(III) catalysis. 1,2-orthoesters are stable and can be stored for longer periods without any degradation or decomposition. We envisioned that 1,2-orthoesters are highly useful synthons for the synthesis of those azido glycosides and cyano compounds where the C-2 hydroxyl group needs to become free for further chemistry. In this study, we explored utility of gold (III) catalysis for opening of propargyl 1,2-orthoesters by N- and C- nucleophiles. en_US
dc.language.iso en en_US
dc.subject 2014
dc.subject Carbohydrates en_US
dc.subject Glycosides en_US
dc.title Nucleophilic Addition Reactions on Glycosyl 1,2-Orthoesters en_US
dc.type Thesis en_US
dc.type.degree BS-MS en_US
dc.contributor.department Dept. of Chemistry en_US
dc.contributor.registration 20091028 en_US


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  • MS THESES [1705]
    Thesis submitted to IISER Pune in partial fulfilment of the requirements for the BS-MS Dual Degree Programme/MSc. Programme/MS-Exit Programme

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