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HIstome—a relational knowledgebase of human histone proteins and histone modifying enzymes

Show simple item record KHARE, SATYAJEET P. en_US HABIB, FARHAT en_US Sharma, Rahul en_US Gadewal, Nikhil en_US Gupta, Sanjay en_US GALANDE, SANJEEV en_US 2019-07-23T11:12:48Z 2019-07-23T11:12:48Z 2012-12 en_US
dc.identifier.citation Nucleic Acids Research, 40(D1), D337-D342. en_US
dc.identifier.issn 0305-1048 en_US
dc.identifier.issn 1362-4962 en_US
dc.identifier.uri en_US
dc.description.abstract Histones are abundant nuclear proteins that are essential for the packaging of eukaryotic DNA into chromosomes. Different histone variants, in combination with their modification ‘code’, control regulation of gene expression in diverse cellular processes. Several enzymes that catalyze the addition and removal of multiple histone modifications have been discovered in the past decade, enabling investigations of their role(s) in normal cellular processes and diverse pathological conditions. This sudden influx of data, however, has resulted in need of an updated knowledgebase that compiles, organizes and presents curated scientific information to the user in an easily accessible format. Here, we present HIstome, a browsable, manually curated, relational database that provides information about human histone proteins, their sites of modifications, variants and modifying enzymes. HIstome is a knowledgebase of 55 human histone proteins, 106 distinct sites of their post-translational modifications (PTMs) and 152 histone-modifying enzymes. Entries have been grouped into 5 types of histones, 8 types of post-translational modifications and 14 types of enzymes that catalyze addition and removal of these modifications. The resource will be useful for epigeneticists, pharmacologists and clinicians. en_US
dc.language.iso en en_US
dc.publisher Oxford University Press en_US
dc.subject Histome en_US
dc.subject Relational knowledgebase en_US
dc.subject Histone proteins en_US
dc.subject Histone modifying enzymes en_US
dc.subject DNA into chromosomes en_US
dc.subject 2012 en_US
dc.title HIstome—a relational knowledgebase of human histone proteins and histone modifying enzymes en_US
dc.type Article en_US
dc.contributor.department Dept. of Biology en_US
dc.identifier.sourcetitle Nucleic Acids Research en_US
dc.publication.originofpublisher Foreign en_US

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