Isolation and structure elucidation of halymeniaol, a new antimalarial sterol derivative from the red alga Halymenia floresii

GURUNG, PRATIMA; Subrayan, Parameswaran; WATVE, MILIND; KARMODIYA, KRISHANPAL; MEESALA, SRINU

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dc.contributor.author	MEESALA, SRINU	en_US
dc.contributor.author	GURUNG, PRATIMA	en_US
dc.contributor.author	KARMODIYA, KRISHANPAL	en_US
dc.contributor.author	Subrayan, Parameswaran	en_US
dc.contributor.author	WATVE, MILIND	en_US
dc.date.accessioned	2019-09-09T11:35:44Z
dc.date.available	2019-09-09T11:35:44Z
dc.date.issued	2018	en_US
dc.identifier.citation	Journal of Asian Natural Products Research, 20(4), 391-398.	en_US
dc.identifier.issn	1028-6020	en_US
dc.identifier.issn	1477-2213	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/3951
dc.identifier.uri	https://doi.org/10.1080/10286020.2017.1342636	en_US
dc.description.abstract	A new mono-hydroxy acetylated sterol derivative: 12β-hydroxy-3β, 15α, 16β-triacetoxy-cholest-5-en-7-one (halymeniaol) (1), and cholesterol (2) were isolated from the marine red alga Halymenia floresii. The structure of the compound 1 (halymeniaol) was established from its spectral data, derived from HRMS/MS and 2D NMR. Compound 1 exhibited growth inhibitory activity against chloroquine-resistant Plasmodium falciparum 3D7 strain with an IC50 of 3.0 μM.	en_US
dc.language.iso	en	en_US
dc.publisher	Taylor & Francis	en_US
dc.subject	Algae	en_US
dc.subject	Sterols	en_US
dc.subject	NMR & mass spectrometry	en_US
dc.subject	Natural products	en_US
dc.subject	Antimalarial activity	en_US
dc.subject	2018	en_US
dc.title	Isolation and structure elucidation of halymeniaol, a new antimalarial sterol derivative from the red alga Halymenia floresii	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Biology	en_US
dc.identifier.sourcetitle	Journal of Asian Natural Products Research	en_US
dc.publication.originofpublisher	Foreign	en_US