Theses submitted to IISER Pune in partial fulfilment of the requirements of the BS-MS dual degree and Ph.D programmes. Also, project reports submitted by the students.
The phenomenon of using architectural heritage as a filming location attracts multiple effects, including site recognition, financial impact, and film-induced tourism, among others. The theorisation of this phenomenon is ...
Carbenes, especially N-heterocyclic carbenes (NHCs), are well-recognised as strong σ-donor ligands for both transition metals and main-group elements. These donor ligands have significantly advanced and transformed the ...
Cell-matrix adhesion is fundamental to cell survival, signalling, and mechanosensing, and its dysregulation is a hallmark of cancer progression. In breast cancer, progressive extracellular matrix stiffening profoundly ...
Lipids are the integral component of membranes and serve key biological functions. The endoplasmic reticulum (ER) acts as a hub for lipid synthesis and transport. VAMP Associated Protein B (VAPB/VAP) is an ER-based, ...
Cell-matrix adhesion plays a vital role in maintaining the juxtanuclear ribbon organization of the Golgi apparatus along microtubules (MTs); however, how adhesion-dependent signalling is coupled to motor-driven Golgi ...
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder marked by progressive loss of motor function. It is a multigenic disease with complex pathophysiology, diverse clinical manifestations and multifactorial ...
Epithelial integrity is maintained through coordinated regulation of cell–cell adhesion, apico basal polarity, and transcriptional programs that preserve epithelial identity. Disruption of these processes underlies ...
Epithelial-to-Mesenchymal Transition (EMT) and its reverse, Mesenchymal-to-Epithelial Transition (MET), underlie essential physiological processes, such as development and wound healing, while also driving pathological ...
The glycocalyx, a dense layer of glycans on the cell surface, plays a fundamental role in mediating cellular communication, adhesion, and signal transduction. Among its key constituents, heparan sulfate (HS) is a highly ...
Peptides offer several advantages in drug discovery due to their ability to mimic natural biological molecules, enabling high target specificity and potency. Their biological activity is influenced by sequence, structure, ...
In bacterial chemotaxis, methyl-accepting chemotaxis proteins (MCPs) detect environmental cues and initiate a phosphorelay signal. In Myxococcus xanthus, the Frz pathway regulates motility in response to these cues. MCPs ...
Defects play a fundamental role in determining the mechanical behavior of materials.
In crystalline solids, their nature and dynamics are well understood, as dislocations and vacancies mediate plastic deformation. However, ...
Microtubule (MT) polymerization and motor driven transport drive cellular processes like intracellular transport and cell division. In this thesis, we study how physical and chemical factors collectively affect microtubule ...
The advent of genome sequencing technologies has revealed the presence of a myriad of proteins in the mammalian system, many of which are poorly characterised. The presence of these orphan proteins imply that our understanding ...
This thesis presents two projects centered on the computational design and analysis of thermoelectric materials derived from half-Heusler and double half-Heusler compounds. The research is motivated by the growing need to ...
The impact of an enhanced mutation rate on evolutionary dynamics is extensively studied. For instance, mutator genotypes with high mutation rates speed up adaptation by increasing the supply of beneficial mutations. Many ...
Lipids molecules often share highly similar structural frameworks among species, however minor variation in their chemical composition influence their interactions with proteins interactors. Many of these interactions are ...
Biological systems at micrometer scales and below often operate in crowded, highly viscous environments characterized by persistent stochastic thermal fluctuations. Diffusion is incessant and plays an important role in ...
The equatorial Indian Ocean is widely recognized as a key region for Madden–Julian Oscillation (MJO) convective initiation, but it does not behave as a single, uniform initiation basin. Instead, strong zonal and seasonal ...
The zonal-mean representation of the Hadley circulation provides a simple and effective framework for describing the global tropical circulation. However, such zonal averaging may obscure important regional meridional ...