Theses submitted to IISER Pune in partial fulfilment of the requirements of the BS-MS dual degree and Ph.D programmes. Also, project reports submitted by the students.
The double helix is the most common and very important structural motif in nucleic acids. In comparison, double helix motifs are rare in proteins and other biomolecules. Nevertheless, gramicidins A-D and feglymicin, linear ...
The form and function of biological systems are moulded by the action of ecological and evolutionary forces at different organisational scales. This thesis uses theoretical and empirical tools to investigate these processes ...
Environmental pollution and its consequences have become a major threat in recent couple of years. Water pollution among them become major menace and the problem will be even worse in the near future. In the 21st century, ...
A number of stem cells in Drosophila and mammalian systems are partially polarised epithelial cells that have a lateral and basal domain but no apical domain. As a result of their differentiation, an apical domain develops, ...
Mitochondria manage essential functions such as ATP production, Ca 2+ homeostasis and apoptotic signalling but are prone to damage. Surveillance mechanisms have evolved to selectively detect and rid the network of damaged ...
Protein aggregation is a common feature observed in several neurodegenerative disorders. Their presence can affect cellular homeostasis in several ways and could prove to be valuable clues to understand neural disease ...
Spiroplasma is a cell-wall less helical bacterium. Electron microscopy studies show the presence of a flat, monolayered and membrane-bound ribbon-like cytoskeleton structure which consists of Fibril and 5 MreB paralogs. ...
The unique optoelectronic properties of three-dimensionally confined semiconductor nanocrystals or quantum dots (QDs) have rendered them a special place in light harvesting studies, including photocatalysis. As a result, ...
Photoredox catalysis has emerged as a powerful and versatile tool in organic synthesis, enabling
diverse chemical transformations that were previously challenging or inaccessible. This thesis
explores the principles, ...
Synthetic polymers based on L-amino acids have attracted much attention because of their excellent biocompatibility and diverse functionality which provides them improved hydrophilicity and an opportunity for further ...
A host of dynamin superfamily proteins undertake diverse membrane-active processes in cells. Classical dynamins are paradigmatic membrane fission catalysts that release vesicles by acting on the neck of nascent endocytic ...
Covalent Organic Frameworks (COFs) are a new class of crystalline polymers constructed using reticular chemistry. The functionalizable precursors connected by covalent bonds give rise to graphene like 2D layers. These ...
TAR RNA binding protein (TRBP) has been known for its involvement in the RNA interference (RNAi) pathway. TRBP aids the Dicer-mediated pre-miRNA cleavage and recruitment of the RISC complex. While doing so, TRBP binds to ...
The biological lipid membrane encloses cellular components and cell organelles in protective layers and does not allow the permeation of highly polar solutes. However, the proper operation of cellular functions depends on ...
The Standard Model (SM) explains three out of four fundamental forces except for gravity.
One of the primary limitations of SM is a mass hierarchy problem, and the other is the inability to explain the presence of dark ...
Thermoelectric materials are a fascinating class of materials that possess the unique ability to directly convert heat energy into electrical energy and vice versa. In recent times, they have attracted significant attention ...
Membrane tubulation coupled to fission is fundamental to numerous cellular processes. It manifests in all known forms of vesicular trafficking and its precise regulation is critical for inter and intra-cellular cross-talk. ...
This thesis investigates the charge density waves (CDW) in two transition metal dichalcogenides (TMDC) using scanning tunneling microscopy (STM). Doping and strain are used to tune the CDWs, helping to understand the ...
The primary objective of my doctoral research was to elucidate the fundamental principles
underlying ion channel formation through non-covalent interactions and to investigate their
anion selectivity within the lipid ...
The α,β-unsaturated γ-lactams represent important synthetic targets due to their presence in natural products, diverse biological activities, and their utility as building blocks for the synthesis of other compounds. These ...