GOTTIMUKKALA, KAMALVISHNU PRASAD(Dept. of Biology, 2013-08)
T lymphocyte development and differentiation is a multi-step process that begins in the thymus and completed in the periphery. Sequential development of thymocytes is dependent on T cell receptor (TCR) signaling and an ...
SATB1 and SATB2 are members of special AT-rich binding protein family, a class of chromatin organizers and gene regulators. SATB1 has been shown to play seminal roles in development and differentiation of T cells whereas ...
Tumor development and metastasis involves programmed and progressive changes in expression of large number of genes. The precise molecular mechanisms and signaling pathways regulating the expression of these genes are ...
Abstract:
Special AT-rich binding protein 1 (SATB1) is a global chromatin organizer that links higher-order chromatin architecture to gene regulation. In addition to its key role in gene regulation, it is also known to ...
SATB1 is a chromatin organizer protein enriched in T cells. It plays a crucial role in differentiation of naïve CD4+ T cells. Transcriptome analysis performed in our laboratory suggested that multiple promoters are involved ...
SATB1 is a T-lineage-enriched chromatin organizer and global gene regulator. SATB1 regulates multitude of genes important for T-cell survival, positive and negative selection. SATB1 binds to its target loci and recruits ...
Malaria is caused by the Plasmodium parasites and is transmitted through the bites of female Anopheles mosquito. Of the 5 Plasmodium species that cause malaria, P. falciparum and P. vivax cause the greatest threat. The ...
The competency of an organism to sense the stressful conditions and appropriately respond to them determines its survivability. Insulin/IGF-1 signaling is one of the most studied pathways that sense different stress ...
Hydra is a freshwater polyp belonging to the phylum Cnidaria. These polyps are known
to exhibit tremendous regenerating potential. It is still unclear how the regenerating
tissue is reorganized, how the complex interplay ...
Pro-inflammatory Th17 cells are critical for mucosal immune responses and also have implications in development of autoimmune disorders. So far, Th17 regulatory networks have been investigated using mouse models, but the ...
Malaria, the mosquito-borne disease, is one of the toughest global health crises we face
today. In 2018, it was responsible for 228 million infections and 405,000 deaths worldwide, with children alone accounting for 67% ...
The basic body plan is determined within hours to a few days of embryonic development.
This window is characterized by zygotic genome activation, lineage specification and
morphogenetic events during organogenesis. Early ...
Altered insulin-glucose relationship is the focus of type 2 diabetes pathophysiology and treatment. Despite decades of research on the cause and mechanisms of the disorder, there are many inconsistencies and gaps in the ...
Hydra is a Cnidarian with the first polarized body axis in metazoans determined by the Wnt/β-catenin signalling pathway. It also possesses a remarkable ability to regenerate both from small tissue fragments and aggregates ...
Specificity protein 1 or Sp1 is a general transcription factor that binds to TATA-less promoters and drives the transcription of their downstream genes. It regulates processes like proliferation, cell cycle, metastasis, ...
Understanding the regulation of gene expression in the context of development is important as it helps in comprehending the processes by which cells differentiate and develop into specific tissues and organs. Cis-regulatory ...
The Special AT-rich sequence Binding proteins SATB1 and SATB2 play a significant role in many biological processes ranging from the development of an organism to disease. SATB1 and SATB2 show 61% sequence identity in the ...