Peptide toxins produced by venomous animals serve as powerful tools for unraveling the mechanisms of modulation of ion channel proteins they target. My thesis work focuses on studying the mechanism of activation of the ...
The transient receptor potential vanilloid 1 (TRPV1) ion channel is activated by a diverse range of stimuli including noxious heat and pain-inducing agents. The molecular mechanisms underlying this polymodal channel ...
Choline is an essential nutrient for mammalian cells that acts as a substrate for Kennedy pathway, wherein, upon cellular internalization, it is sequentially converted into phosphocholine and cytidine 5'-diphosphocholine ...
Recent advances in structural biology show that lipids interact intimately with a wide range of membrane proteins, including ion channels, transporters, and membrane enzymes, implying that protein-lipid interfaces play ...