Abstract:
The thesis entitled Identification of Novel Glycosyl Donor Chemistry and Syntheses of
Oligosaccharides is divided into four chapters. Chapter one reveals the discussion of
carbohydrates and glycosylation; various types of glycosylations, factors determining the
stereochemical outcome of glycosylation, a detailed study about the historical development of
glycosyl donors and future scope for the field of glycosylation were discussed. Chapter two
depicts the development of nucleofuge generating glycosylation by the remote activation of
hydroxybenzotriazolyl glycosyl donors, activation, and their application for the synthesis of O-,
C-, and N-glycosides. Chapter three illustrates utility of newly developed regenerative
glycosylation by the synthesis of the linear and branched highmannan core of the HIV1-gp120
complex. Chapter four describes efforts towards the synthesis of the most complex and branched
oligosaccharide Arabinogalactan (AG) present on the surface of Mycobacterium tuberculosis cell
wall.
