Identification of Novel Glycosyl Donor Chemistry and Syntheses of Oligosaccharides

Abstract

The thesis entitled Identification of Novel Glycosyl Donor Chemistry and Syntheses of Oligosaccharides is divided into four chapters. Chapter one reveals the discussion of carbohydrates and glycosylation; various types of glycosylations, factors determining the stereochemical outcome of glycosylation, a detailed study about the historical development of glycosyl donors and future scope for the field of glycosylation were discussed. Chapter two depicts the development of nucleofuge generating glycosylation by the remote activation of hydroxybenzotriazolyl glycosyl donors, activation, and their application for the synthesis of O-, C-, and N-glycosides. Chapter three illustrates utility of newly developed regenerative glycosylation by the synthesis of the linear and branched highmannan core of the HIV1-gp120 complex. Chapter four describes efforts towards the synthesis of the most complex and branched oligosaccharide Arabinogalactan (AG) present on the surface of Mycobacterium tuberculosis cell wall.