dc.contributor.author |
Thadke, Shivaji A. |
en_US |
dc.contributor.author |
HRIDYA, V. M. |
en_US |
dc.contributor.author |
Perera, J. Dinithi R. |
en_US |
dc.contributor.author |
Gil, Roberto R. |
en_US |
dc.contributor.author |
MUKHERJEE, ARNAB |
en_US |
dc.contributor.author |
H. Ly, Danith |
en_US |
dc.date.accessioned |
2019-12-24T11:54:22Z |
|
dc.date.available |
2019-12-24T11:54:22Z |
|
dc.date.issued |
2018-11 |
en_US |
dc.identifier.citation |
Communications Chemistry, 4, 15. |
en_US |
dc.identifier.issn |
2041-1723 |
en_US |
dc.identifier.uri |
http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/4264 |
|
dc.identifier.uri |
https://doi.org/10.1038/s42004-018-0080-5 |
en_US |
dc.description.abstract |
An impressive array of antigene approaches has been developed for recognition of double helical DNA over the past three decades; however, few have exploited the ‘Watson–Crick’ base-pairing rules for establishing sequence-specific recognition. One approach employs peptide nucleic acid as a molecular reagent and strand invasion as a binding mode. However, even with integration of the latest conformationally-preorganized backbone design, such an approach is generally confined to sub-physiological conditions due to the lack of binding energy. Here we report the use of a class of shape-selective, bifacial nucleic acid recognition elements, namely Janus bases, for targeting double helical DNA or RNA. Binding occurs in a highly sequence-specific manner under physiologically relevant conditions. The work may provide a foundation for the design of oligonucleotides for targeting the secondary and tertiary structures of nucleic acid biopolymers. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Nature Publishing Group |
en_US |
dc.subject |
DNA |
en_US |
dc.subject |
RNA |
en_US |
dc.subject |
2018 |
en_US |
dc.title |
Shape selective bifacial recognition of double helical DNA |
en_US |
dc.type |
Article |
en_US |
dc.contributor.department |
Dept. of Chemistry |
en_US |
dc.identifier.sourcetitle |
Communications Chemistry |
en_US |
dc.publication.originofpublisher |
Foreign |
en_US |