dc.contributor.author |
REJA, RAHI M. |
en_US |
dc.contributor.author |
MISRA, RAJKUMAR |
en_US |
dc.contributor.author |
GOPI, HOSAHUDYA N. |
en_US |
dc.date.accessioned |
2020-02-11T10:36:27Z |
|
dc.date.available |
2020-02-11T10:36:27Z |
|
dc.date.issued |
2019-01 |
en_US |
dc.identifier.citation |
ChemNanoMat, 5(1), 51-54. |
en_US |
dc.identifier.issn |
2199-692X |
en_US |
dc.identifier.uri |
http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/4415 |
|
dc.identifier.uri |
https://doi.org/10.1002/cnma.201800366 |
en_US |
dc.description.abstract |
A new approach for the construction of two-helix motifs from helix modules and planar 1,4,5,8-naphthalenetetracarboxylic diimide (NDI) is described. The single crystal conformations of two different types of two-helix motifs consisting of achiral alpha-peptide C-10-helix (3(10)) and chiral alpha,gamma-hybrid peptide C-12-helix revealed that the helices adopted antiparallel orientations across the planar NDI with 2-fold symmetry. The crystal conformations of two-helix motifs were further explored to design electrical conducting peptide foldamer by introducing electron rich pyrene (p-type) as a side-chain in the alpha,gamma-hybrid helix. The two-helix motif with charge transferable pyrene (p-type)-NDI (n-type) combination showed better electrical conductivity compared to the two-helix motif without pyrene side-chain. Moreover, the crystal conformations also provided molecular insight into the peptide orientation of NDI-peptide conjugates. The two-helix motifs described here may serve as potential molecular scaffolds to design novel conductive peptide foldamers and self-assembling biomaterials. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Wiley |
en_US |
dc.subject |
Peptides |
en_US |
dc.subject |
Two-helix motifs |
en_US |
dc.subject |
Crystal conformation |
en_US |
dc.subject |
Charge transfer |
en_US |
dc.subject |
Conductivity |
en_US |
dc.subject |
2019 |
en_US |
dc.title |
Engineering Two-Helix Motifs through NDI Linker: A Modular Approach for Charge Transferable Conductive Foldamers Design |
en_US |
dc.type |
Article |
en_US |
dc.contributor.department |
Dept. of Chemistry |
en_US |
dc.identifier.sourcetitle |
ChemNanoMat |
en_US |
dc.publication.originofpublisher |
Foreign |
en_US |