Digital Repository

Cognitive abilities and Brain Connectivity - A resting state fMRI study

Show simple item record

dc.contributor.advisor Purushotham, Archana en_US
dc.contributor.author LALWANI, POORTATA en_US
dc.date.accessioned 2015-05-05T12:48:16Z
dc.date.available 2015-05-05T12:48:16Z
dc.date.issued 2015-05 en_US
dc.identifier.uri http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/456
dc.description.abstract There are an increasing number of studies that are investigating how intrinsic (i.e. resting-state) functional connectivity correlates with cognitive abilities. However, our current understanding about the neural basis of inter-individual differences in cognitive abilities among healthy subjects is limited. Here we investigate correlation of MR-based intrinsic connectivity with multi-domain cognitive abilities in twenty-five healthy male subjects. Our results show that several cognitive abilities from different domains like music perception, empathy quotient, emotion recognition, mathematical abilities, logical reasoning, executive functions like working memory, response inhibition, fluency etc., attention, mental rotation tasks, motor speed, memory and language ability like comprehension, vocabulary, memory etc. are strongly positively correlated with each other. Connectivity within the task-negative network (TNN) is does not appear to correlate with test performance while connectivity within task positive networks (TPN) as also between TPN and TNN are correlated with test performance, suggesting that TPN connectivity, but not TNN connectivity, subserves inter-individual differences in cognitive abilities. Each cognitive test showed score correlation with specific Regions of Interest (ROI) pairs. Most of these ROIs have also been shown by previous studies to be activated by the respective tasks. Thus we show that even at rest, the functional architecture of the brain, and in particular of those regions invoked by the task, correlates with cognitive performance across a wide range of cognitive domains. en_US
dc.language.iso en en_US
dc.subject 2015
dc.subject resting state en_US
dc.subject fMRI en_US
dc.subject cognitive test en_US
dc.subject cognition en_US
dc.subject functional connectivity en_US
dc.subject intrinsic connectivity networks en_US
dc.title Cognitive abilities and Brain Connectivity - A resting state fMRI study en_US
dc.type Thesis en_US
dc.type.degree BS-MS en_US
dc.contributor.department Dept. of Biology en_US
dc.contributor.registration 20101082 en_US


Files in this item

This item appears in the following Collection(s)

  • MS THESES [1705]
    Thesis submitted to IISER Pune in partial fulfilment of the requirements for the BS-MS Dual Degree Programme/MSc. Programme/MS-Exit Programme

Show simple item record

Search Repository


Advanced Search

Browse

My Account