The transient receptor potential vanilloid 1 (TRPV1) ion channel is activated by a diverse range of stimuli including noxious heat and pain-inducing agents. The molecular mechanisms underlying this polymodal channel ...
Choline is an essential nutrient for mammalian cells that acts as a substrate for Kennedy pathway, wherein, upon cellular internalization, it is sequentially converted into phosphocholine and cytidine 5'-diphosphocholine ...
Recent advances in structural biology show that lipids interact intimately with a wide range of membrane proteins, including ion channels, transporters, and membrane enzymes, implying that protein-lipid interfaces play ...