N6-methyladenosine (m6A) RNA methylation has emerged as a regulator of virtually all RNA functions across the domains of life. Among the numerous important functions of m6A, regulation of pluripotency to balance its ...

Diabetes mellitus (DM) is a pandemic metabolic disorder affecting ~537 million adults globally, with ~783 million projected by the year 2045. Type 1 DM (T1DM) and type 2 DM (T2DM) are the two major forms of DM and have ...

Electrochemical processes at the electrode–electrolyte interface are broadly divided into charge-transfer and charge-storage phenomena. Charge-transfer reactions, controlled by electrocatalysts, constitute the core of ...

Carbenes, especially N-heterocyclic carbenes (NHCs), are well-recognised as strong σ-donor ligands for both transition metals and main-group elements. These donor ligands have significantly advanced and transformed the ...

Lipids are the integral component of membranes and serve key biological functions. The endoplasmic reticulum (ER) acts as a hub for lipid synthesis and transport. VAMP Associated Protein B (VAPB/VAP) is an ER-based, ...

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disorder marked by progressive loss of motor function. It is a multigenic disease with complex pathophysiology, diverse clinical manifestations and multifactorial ...

Epithelial-to-Mesenchymal Transition (EMT) and its reverse, Mesenchymal-to-Epithelial Transition (MET), underlie essential physiological processes, such as development and wound healing, while also driving pathological ...

Peptides offer several advantages in drug discovery due to their ability to mimic natural biological molecules, enabling high target specificity and potency. Their biological activity is influenced by sequence, structure, ...

Defects play a fundamental role in determining the mechanical behavior of materials. In crystalline solids, their nature and dynamics are well understood, as dislocations and vacancies mediate plastic deformation. However, ...

The advent of genome sequencing technologies has revealed the presence of a myriad of proteins in the mammalian system, many of which are poorly characterised. The presence of these orphan proteins imply that our understanding ...