Cyanuryl peptide nucleic acid: synthesis and DNA complexation properties

dc.contributor.author	Vysabhattar, Raman	en_US
dc.contributor.author	GANESH, KRISHNA N.	en_US
dc.date.accessioned	2020-10-13T09:55:43Z
dc.date.available	2020-10-13T09:55:43Z
dc.date.issued	2008-02	en_US
dc.identifier.citation	Tetrahedron Letters, 49(8), 1314-1318.	en_US
dc.identifier.issn	0040-4039	en_US
dc.identifier.uri	http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5124
dc.identifier.uri	https://doi.org/10.1016/j.tetlet.2007.12.095	en_US
dc.description.abstract	The synthesis of cyanuryl PNA monomer (CyaPNA) 6 was achieved by direct N-monoalkylation of cyanuric acid with N-(2-Boc-aminoethyl)-N′-(bromoacetyl)glycyl ethyl ester 4. Compound 6 was incorporated as a T-mimic into PNA oligomers and biophysical studies on their triplexes/duplex complexes with complementary DNA oligomers indicated unusual stabilization of PNA:DNA hybrids when the cyanuryl unit was located in the middle of the PNA oligomer.	en_US
dc.language.iso	en	en_US
dc.publisher	Elsevier B.V.	en_US
dc.subject	PNA	en_US
dc.subject	Cyanuryl PNA	en_US
dc.subject	2008	en_US
dc.title	Cyanuryl peptide nucleic acid: synthesis and DNA complexation properties	en_US
dc.type	Article	en_US
dc.contributor.department	Dept. of Chemistry	en_US
dc.identifier.sourcetitle	Tetrahedron Letters	en_US
dc.publication.originofpublisher	Foreign	en_US