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Cascade reaction based fluorescent probe for detection of hydrogen sulfide

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dc.contributor.advisor TALUKDAR, PINAKI en_US
dc.contributor.author MISHRA, PRATYUSH KUMAR en_US
dc.date.accessioned 2015-05-07T12:13:21Z
dc.date.available 2015-05-07T12:13:21Z
dc.date.issued 2015-05 en_US
dc.identifier.uri http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/522
dc.description.abstract Hydrogen sulfide in an essential gasotransmitter that controls several physiological and pathological functions such as, cardiovascular protection, antioxidative effects, cell growth regulation, cell signaling, and apoptosis. In recent years, development of fluorescent H2S probe that work via cascade reaction process, is of great interest. In the present work, we have developed a new probe based on the azide to amine reduction followed by Pinner cyclization to form iminocoumarin as reporter molecule. The probe showed selective response to hydrogen sulfide over other analytes with t1/2 = 6.1 min, 31-fold fluorescence enhancement and the limit of detection 169 nM. The probe was also permeable through the cell membranes and its application in live cell imaging of H2S was also demonstrated using HeLa cells. en_US
dc.language.iso en en_US
dc.subject 2015
dc.subject Fluorescense en_US
dc.subject Probe en_US
dc.subject Hydrogen Sulfide en_US
dc.subject Detection en_US
dc.title Cascade reaction based fluorescent probe for detection of hydrogen sulfide en_US
dc.type Thesis en_US
dc.type.degree BS-MS en_US
dc.contributor.department Dept. of Chemistry en_US
dc.contributor.registration 20101092 en_US


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  • MS THESES [1705]
    Thesis submitted to IISER Pune in partial fulfilment of the requirements for the BS-MS Dual Degree Programme/MSc. Programme/MS-Exit Programme

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