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Neuronal pattern separation in the olfactory bulb improves odor discrimination learning

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dc.contributor.author Gschwend, Olivier en_US
dc.contributor.author ABRAHAM, NIXON M. en_US
dc.contributor.author Lagier, Samuel en_US
dc.contributor.author Begnaud, Frederic en_US
dc.contributor.author Rodriguez, Ivan en_US
dc.contributor.author Carleton, Alan en_US
dc.date.accessioned 2020-10-26T06:38:01Z
dc.date.available 2020-10-26T06:38:01Z
dc.date.issued 2015-10 en_US
dc.identifier.citation Nature Neuroscience, 18(10). en_US
dc.identifier.issn 1097-6256 en_US
dc.identifier.issn 1546-1726 en_US
dc.identifier.uri http://dr.iiserpune.ac.in:8080/xmlui/handle/123456789/5265
dc.identifier.uri https://doi.org/10.1038/nn.4089 en_US
dc.description.abstract Neuronal pattern separation is thought to enable the brain to disambiguate sensory stimuli with overlapping features, thereby extracting valuable information. In the olfactory system, it remains unknown whether pattern separation acts as a driving force for sensory discrimination and the learning thereof. We found that overlapping odor-evoked input patterns to the mouse olfactory bulb (OB) were dynamically reformatted in the network on the timescale of a single breath, giving rise to separated patterns of activity in an ensemble of output neurons, mitral/tufted (M/T) cells. Notably, the extent of pattern separation in M/T assemblies predicted behavioral discrimination performance during the learning phase. Furthermore, exciting or inhibiting GABAergic OB interneurons, using optogenetics or pharmacogenetics, altered pattern separation and thereby odor discrimination learning in a bidirectional way. In conclusion, we propose that the OB network can act as a pattern separator facilitating olfactory stimulus distinction, a process that is sculpted by synaptic inhibition. en_US
dc.language.iso en en_US
dc.publisher Nature Publishing Group en_US
dc.subject Sensory Information en_US
dc.subject Gamma-Oscillations en_US
dc.subject Feedback-Control en_US
dc.subject Dentate Gyrus en_US
dc.subject Representations en_US
dc.subject Mouse en_US
dc.subject Decorrelation en_US
dc.subject Interneurons en_US
dc.subject Inhibition en_US
dc.subject Accuracy en_US
dc.subject 2015 en_US
dc.title Neuronal pattern separation in the olfactory bulb improves odor discrimination learning en_US
dc.type Article en_US
dc.contributor.department Dept. of Biology en_US
dc.identifier.sourcetitle Nature Neuroscience en_US
dc.publication.originofpublisher Foreign en_US


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